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Sarcoidosis is also accompanied by psychological distress and symptoms of anxiety and depression, which are also associated with fatigue. [24] The cutaneous symptoms vary, and range from rashes and noduli (small bumps) to erythema nodosum , granuloma annulare, or lupus pernio .
Scar sarcoid (also known as "Sarcoidosis in scars") is a cutaneous condition characterized by infiltration and elevation of tattoos and old flat scars due to sarcoidosis. [2]: 710 Mucosal sarcoidosis is a cutaneous condition characterized by pinhead-sized papules that may be grouped and fused together to form a flat plaque. [2]: 711
Löfgren syndrome is a type of acute sarcoidosis, [1] an inflammatory disorder characterized by swollen lymph nodes in the chest, tender red nodules on the shins, fever and arthritis. [2] It is more common in women than men, and is more frequent in those of Scandinavian, Irish, African and Puerto Rican heritage.
Other symptoms due to sarcoidosis of other organs may be uveitis (inflammation of the uveal layer in the eye), dyspnoea (shortness of breath), arthralgia (joint pains), lupus pernio (a red skin rash, usually of the face), erythema nodosum (red skin lumps, usually on the shins), and symptoms of liver involvement or heart involvement (heart failure).
Heerfordt syndrome is a rare manifestation of sarcoidosis. The symptoms include inflammation of the eye ( uveitis ), swelling of the parotid gland , chronic fever , and in some cases, palsy of the facial nerves .
The generally acknowledged theory proposes that a complex interplay among genetic predisposition, immunological dysregulation, and environmental factors leads to sarcoidosis. [3] It is believed that an augmented cell-mediated immune response to one or more undiscovered antigens is the cause of the granulomatous inflammation. [ 6 ]
Testicular sarcoidosis can present as a diffuse painless scrotal mass or can mimic acute epididymo-orchitis. Usually it appears with systemic manifestations of the disease. [ 3 ] Since it causes occlusion and fibrosis of the ductus epididymis, fertility may be affected. [ 4 ]
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