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Modafinil, sold under the brand name Provigil among others, is a central nervous system (CNS) stimulant and eugeroic (wakefulness promoter) medication used primarily to treat narcolepsy, [3] [8] [15] a sleep disorder characterized by excessive daytime sleepiness and sudden sleep attacks. [16]
Methamphetamine accounts for 84% of illegal drug use in Japan and has a relatively high street value in the country (around 10 times the street value in production regions). [18] Netherlands: Unenforced: Illegal: Illegal: Illegal: Methamphetamine is not approved for medical use in The Netherlands. It falls under Schedule I of the Opium Act. [19]
At steady state, the systemic exposure for armodafinil is 1.8 times the exposure observed after a single dose. The concentration-time profiles of the (R)-(−)-enantiomer following a single dose of 50 mg Nuvigil or 100 mg Provigil (modafinil being a 1:1 mixture of (R)-(−)- and (S)-(−)- enantiomers
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Clinical pharmacokinetics of methamphetamine [12] Route Dose Bioavailability C max (g/L) Tmax (minutes) T 1/2 (hours) Time to peak effect (minutes) Intravenous 30 mg 100% 108 22 6 9.1 0.8 15 Oral 30 mg 67% 94.1 216 9.1 18 2 Smoking 30 mg 67%/ 90 10% 47 6 150 30 12 1 180 Intra-nasal 50 mg 79% 113 8 169 8 11 1 15
A Riverside County Sheriff's Department sting operation gone wrong last week put 60 pounds of methamphetamine in the hands of a narcotics trafficker, the department has admitted.
The botulinum toxin as the most toxic substance known has an LD 50 value of 1 ng/kg, while the most non-toxic substance water has an LD 50 value of more than 90 g/kg; a difference of about 1 in 100 billion, or 11 orders of magnitude. As with all measured values that differ by many orders of magnitude, a logarithmic view is advisable.
Officials later found 3,750 grams of drugs and precursor ... Officials estimated the street value of the drugs to be more than $2.2 million, making it the largest illicit pharmaceutical seizure in ...