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2. Effects of nicotine on human brain development - Wikipedia

   en.wikipedia.org/wiki/Effects_of_nicotine_on...

   When nicotine enters the brain it stimulates, among other activities, the midbrain dopaminergic neurons situated in the ventral tegmental area and pars compacta. [12] Nicotine negatively affects the prefrontal cortex of the developing brain. Prenatal nicotine exposure can result in long-term adverse effects to the developing brain.

3. Nicotinic acetylcholine receptor - Wikipedia

   en.wikipedia.org/wiki/Nicotinic_acetylcholine...

   Nicotinic receptors get their name from nicotine which does not stimulate the muscarinic acetylcholine receptors but selectively binds to the nicotinic receptors instead. [ 3 ] [ 4 ] [ 5 ] The muscarinic acetylcholine receptor likewise gets its name from a chemical that selectively attaches to that receptor— muscarine . [ 6 ]

4. Nicotine - Wikipedia

   en.wikipedia.org/wiki/Nicotine

   A 2018 Cochrane review found that, in rare cases, nicotine replacement therapy can cause non-ischemic chest pain (i.e., chest pain that is unrelated to a heart attack) and heart palpitations, but does not increase the incidence of serious cardiac adverse events (i.e., myocardial infarction, stroke, and cardiac death) relative to controls. [47]

5. Microdosing nicotine: Could it actually be good for your ...

   www.aol.com/lifestyle/microdosing-nicotine-could...

   But nicotine does have an effect on one’s brain. “At low concentrations, nicotine does decrease anxiety, whereas at high doses it increases anxiety,” Bhatnagar tells Yahoo. “It can also ...

6. 7 Easy Ways to Stimulate Your Brain As You Age ... - AOL

   www.aol.com/lifestyle/7-easy-ways-stimulate...

   Engaging in activities that stimulate your brain can help curb these issues. "Much like muscle and that old saying 'if you don’t use it, you lose it,' using your brain can help protect it, to an ...

7. Nicotinic agonist - Wikipedia

   en.wikipedia.org/wiki/Nicotinic_agonist

   α4β2 nAChRs contain two α4 subunits and three β2 subunits, therefore it has two binding sites for ACh and other agonists. α4β2 nAChRs account for approximately 90% of the nAChRs in the human brain and when chronically exposed to nicotine or other nicotine agonists leads to increase in density of α4β2 receptors which is the opposite of ...

8. Alpha-4 beta-2 nicotinic receptor - Wikipedia

   en.wikipedia.org/wiki/Alpha-4_beta-2_nicotinic...

   A 2015 review noted that stimulation of the α4β2 nicotinic receptor in the brain is responsible for certain improvements in attentional performance; [4] among the nicotinic receptor subtypes, nicotine has the highest binding affinity at the α4β2 receptor (k i =1 nM), which is also the primary biological target that mediates nicotine's ...

9. Health effects of tobacco - Wikipedia

   en.wikipedia.org/wiki/Health_effects_of_tobacco

   Another study considered a possible role of nicotine in reducing Parkinson's risk: nicotine stimulates the dopaminergic system of the brain, which is damaged in Parkinson's disease, while other compounds in tobacco smoke inhibit MAO-B, an enzyme which produces oxidative radicals by breaking down dopamine. [151]