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Macroamylasemia is the presence of macroamylase in the blood. Macroamylase is a complex of the enzyme amylase bound to other proteins forming a larger molecule. [1] Macroamylase is typically composed of immunoglobulin A (IgA, 70%) and less often of immunoglobulin G (IgG, 30%). The association of amylase with some drugs has also been reported. [2]
Other causes include high levels of blood fats, high blood calcium, some medications, and certain genetic disorders, such as cystic fibrosis, among others. [1] Smoking increases the risk of both acute and chronic pancreatitis. [3] [4] Diagnosis of acute pancreatitis is based on a threefold increase in the blood of either amylase or lipase. [1]
Liver function tests (LFTs or LFs), also referred to as a hepatic panel or liver panel, are groups of blood tests that provide information about the state of a patient's liver. [1] These tests include prothrombin time (PT/INR), activated partial thromboplastin time (aPTT), albumin , bilirubin (direct and indirect), and others.
Acute pancreatitis (AP) is a sudden inflammation of the pancreas.Causes include a gallstone impacted in the common bile duct or the pancreatic duct, heavy alcohol use, systemic disease, trauma, elevated calcium levels, hypertriglyceridemia (with triglycerides usually being very elevated, over 1000 mg/dL), certain medications, hereditary causes and, in children, mumps.
Electrophoresis is a laboratory technique in which the blood serum (the fluid portion of the blood after the blood has clotted) is applied to either an acetate membrane soaked in a liquid buffer, [3] or to a buffered agarose gel matrix, or into liquid in a capillary tube, and exposed to an electric current to separate the serum protein ...
The comprehensive metabolic panel, or chemical screen (CMP; CPT code 80053), is a panel of 14 blood tests that serves as an initial broad medical screening tool. The CMP provides a rough check of kidney function, liver function, diabetic and parathyroid status, and electrolyte and fluid balance, but this type of screening has its limitations.
This can lead to high levels of protein in the urine (proteinuria) and nephrotic syndrome. [8] Several types of amyloidosis, including the AL and AA types, are associated with nephrotic syndrome. [9] Approximately 20% and 40–60% of people with AL and AA amyloidosis respectively progress to end-stage kidney disease requiring dialysis. [9]
Another common finding is high blood calcium levels. [6] Multiple myeloma is considered treatable, but generally incurable. [3] Remissions may be brought about with steroids, chemotherapy, targeted therapy, and stem cell transplant. [3] Bisphosphonates and radiation therapy are sometimes used to reduce pain from bone lesions.