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At autopsy, many patients diagnosed during life with Parkinson's disease are found actually to have MSA, suggesting that the actual incidence of MSA is higher than that estimate. [4] While some suggest that MSA affects slightly more men than women (1.3:1), others suggest that the two sexes are equally likely to be affected.
As Parkinson's is a heterogeneous condition with multiple etiologies, prognostication can be difficult and prognoses can be highly variable. [221] [223] On average, life expectancy is reduced in those with Parkinson's, with younger age of onset resulting in greater life expectancy decreases. [224]
GI symptoms can occur up to 20 years prior to the onset of clinical motor symptoms. [10] [7] The potential involvement of the gut in PD was first suggested over 200 years ago by James Parkinson, who describes PD as “a disordered state of the stomach and bowels (that) may induce a morbid action in a part of the medulla spinalis”. [11]
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Veronica Brown lived with chronic fatigue, depression, and anxiety for over 10 years before she learned they were early signs of Parkinson's disease. Here's how she found relief after diagnosis.
Parkinson's disease patient showing a typical flexed walking posture in advanced stage. Signs and symptoms of Parkinson's disease are varied. Parkinson's disease affects movement, producing motor symptoms. [1] Non-motor symptoms, which include dysautonomia, cognitive and neurobehavioral problems, and sensory and sleep difficulties, are also ...