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The evolutionarily constrained open reading frame is found on a bicistronic transcript which has a downstream ORF encoding the small nuclear ribonucleoprotein polypeptide N. The upstream coding region utilizes the first three exons of the transcript, a region that has been identified as an imprinting center.
An upstream open reading frame (uORF) is an open reading frame (ORF) within the 5' untranslated region (5'UTR) of an mRNA. uORFs can regulate eukaryotic gene expression. [1] [2] Translation of the uORF typically inhibits downstream expression of the primary ORF. However, in some genes such as yeast GCN4, translation of specific uORFs may ...
The protein arises from a bicistronic transcript that also encodes a protein identified as the SNRPN upstream reading frame (SNURF). Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region.
The eukaryotic 5′ UTR also contains cis-acting regulatory elements called upstream open reading frames (uORFs) and upstream AUGs (uAUGs) and termination codons, which have a great impact on the regulation of translation . Unlike prokaryotes, 5′ UTRs can harbor introns in eukaryotes. In humans, ~35% of all genes harbor introns within the 5 ...
Some short open reading frames, [7] also named small open reading frames, [8] abbreviated as sORFs or smORFs, usually < 100 codons in length, [9] that lack the classical hallmarks of protein-coding genes (both from ncRNAs and mRNAs) can produce functional peptides. [10] They encode microproteins or sORFâencoded proteins (SEPs).
An open reading frame (ORF) is a reading frame that has the potential to be transcribed into RNA and translated into protein. It requires a continuous sequence of DNA which may include a start codon, through a subsequent region which has a length that is a multiple of 3 nucleotides, to a stop codon in the same reading frame.
The translation of ATF4 is dependent on upstream open reading frames located in the 5'UTR. [13] The location of the second uORF, aptly named uORF2, overlaps with the ATF4 open-reading frame. During normal conditions, the uORF1 is translated, and then translation of uORF2 occurs only after eIF2-TC has been reacquired.
n/a Ensembl ENSG00000211689 n/a UniProt Q0VGM3 n/a RefSeq (mRNA) NM_001003799 NM_001003806 n/a RefSeq (protein) NP_001003806.1 n/a Location (UCSC) Chr 7: 38.26 – 38.27 Mb n/a PubMed search n/a Wikidata View/Edit Human TCR gamma alternate reading frame protein, also known as TARP, is a human gene. In some non- lymphoid tissues, the unrearranged T cell receptor gamma (TRG@) locus is expressed ...