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Protein phosphatase 2 (PP2), also known as PP2A, is an enzyme that in humans is encoded by the PPP2CA gene. [ 2 ] [ 3 ] The PP2A heterotrimeric protein phosphatase is ubiquitously expressed, accounting for a large fraction of phosphatase activity in eukaryotic cells. [ 4 ]
5518 51792 Ensembl ENSG00000105568 ENSMUSG00000007564 UniProt P30153 Q76MZ3 RefSeq (mRNA) NM_014225 NM_001363656 NM_016891 RefSeq (protein) NP_055040 NP_001350585 NP_055040.2 NP_058587 Location (UCSC) Chr 19: 52.19 – 52.23 Mb Chr 17: 21.17 – 21.19 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform is ...
Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism.Phosphorylation enables the activation or The ability of this widely distributed heterotrimeric enzyme to act on a diverse array of substrates is largely controlled by the nature of its regulatory B subunit.
In contrast, protein phosphatases (PPs) are the primary effectors of dephosphorylation and can be grouped into three main classes based on sequence, structure and catalytic function. The largest class of PPs is the phosphoprotein phosphatase (PPP) family comprising PP1, PP2A, PP2B, PP4, PP5, PP6 and PP7, and the protein phosphatase Mg 2+ - or ...
Phosphatase enzymes are essential to many biological functions, because phosphorylation (e.g. by protein kinases) and dephosphorylation (by phosphatases) serve diverse roles in cellular regulation and signaling. [2] Whereas phosphatases remove phosphate groups from molecules, kinases catalyze the transfer of phosphate groups to molecules from ATP.
5525 226849 Ensembl ENSG00000066027 ENSMUSG00000026626 UniProt Q15172 Q6PD03 RefSeq (mRNA) NM_006243 NM_001199756 NM_144880 RefSeq (protein) NP_001186685 NP_006234 NP_659129 Location (UCSC) Chr 1: 212.29 – 212.36 Mb Chr 1: 191.08 – 191.14 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform is an enzyme ...
Protein CIP2A also known as cancerous inhibitor of PP2A (CIP2A) is a protein that in humans is encoded by the KIAA1524 gene. [5] [6] CIP2A is a regulatory protein involved in the inhibition of the serine-threonine phosphatase activity of Protein phosphatase 2A (PP2A). PP2A is a trimeric enzyme composed of a catalytic C-subunit, a scaffolding A ...
5520 71978 Ensembl ENSG00000221914 ENSMUSG00000022052 UniProt P63151 Q6P1F6 RefSeq (mRNA) NM_001177591 NM_002717 NM_001205188 NM_028032 NM_001360033 NM_001360034 RefSeq (protein) NP_001171062 NP_002708 NP_001192117 NP_082308 NP_001346962 NP_001346963 Location (UCSC) Chr 8: 26.29 – 26.37 Mb Chr 14: 67.25 – 67.31 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Serine/threonine ...