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Swimmer's ear should be treated with antibiotic eardrops, not oral antibiotics. [14] Sinusitis should not be treated with antibiotics because it is usually caused by a virus, and even when it is caused by a bacterium, antibiotics are not indicated except in atypical circumstances as it usually resolves without treatment. [15] Viral ...
Pyrophosphate analogue DNA polymerase inhibitor: 1991 Ganciclovir (Cytovene) [9] Cytomegalovirus (CMV) [10] Competitive nucleoside analogue dGTP inhibitor 1988 Ibacitabine: Herpes labialis: Ibalizumab (Trogarzo) [11] HIV Entry inhibitor 2018 Idoxuridine: Herpes: dU analogue inhibitor 1962 Imiquimod: Genital wart, Basal cell carcinoma, Actinic ...
In regards to bacteria, the idea is to design agents that block virulence rather than kill bacteria en masse, as the current regime results in much more selective pressure (on antibiotic resistance). From the early 1950s onwards, a large number of antibiotics , due to the emergence of multidrug-resistant common pathogen strains (both gram ...
In 2019, global deaths attributable to AMR numbered 1.27 million in 2019. That same year, AMR may have contributed to 5 million deaths and one in five people who died due to AMR were children under five years old. [17] In 2018, WHO considered antibiotic resistance to be one of the biggest threats to global health, food security and development ...
In viruses, an equivalent "cost" is genomic complexity. The high metabolic cost means that, in the absence of antibiotics, a resistant pathogen will have decreased evolutionary fitness as compared to susceptible pathogens. [36] This is one of the reasons drug resistance adaptations are rarely seen in environments where antibiotics are absent.
Antibiotic resistant bacteria are able to transfer copies of DNA that code for a mechanism of resistance to other bacteria even distantly related to them, which then are also able to pass on the resistance genes, resulting in generations of antibiotics resistant bacteria. [11] This initial transfer of DNA is called horizontal gene transfer. [12]
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Antibiotics used in combination may also be antagonistic and the combined effects of the two antibiotics may be less than if one of the antibiotics was given as a monotherapy. [71] For example, chloramphenicol and tetracyclines are antagonists to penicillins. However, this can vary depending on the species of bacteria. [74]