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All PDE5 inhibitors are generally well tolerated. [1] The occurrence of side effects, or adverse drug reactions (ADRs), with PDE5 inhibitors depends on the dose and type of agent. [1] Headache is a very common ADR, occurring in >10% of patients. Other common ADRs include: dizziness, flushing, dyspepsia, nasal congestion or rhinitis. [6]
PDE5 inhibitor drugs are effective in men regardless of why they have erectile dysfunction — including vascular disease, nerve problems, and even psychological causes. [citation needed] PDE5-inhibiting drugs can cause a number of side-effects, including headache, lightheadedness, dizziness, flushing, nasal congestion, and changes in vision.
Sildenafil, tadalafil and other treatments for ED all belong to a class of medications called phosphodiesterase type 5 or PDE5 inhibitors, which dilate the blood vessels that supply blood to the ...
Tadalafil works by inhibiting the effects of cGMP-specific phosphodiesterase type 5 (or PDE5) — an enzyme found in the smooth muscle cells of blood vessels. ... is a PDE5 inhibitor, meaning it ...
ED medications aren’t magic, and a healthcare professional will explain that phosphodiesterase type 5 inhibitors aren’t growth hormones, nor do they treat finishing early or psychological ED.
The major PDE5 inhibitors (a subset of the phosphodiesterase inhibitors) are sildenafil, tadalafil, vardenafil, and avanafil, and although all share the same mechanism of action each has unique pharmacokinetic and pharmacodynamic properties which dictate their suitability in various conditions and their side effect profile. [3]