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Rituximab, sold under the brand name Rituxan among others, is a monoclonal antibody medication used to treat certain autoimmune diseases and types of cancer. [18] It is used for non-Hodgkin lymphoma, chronic lymphocytic leukemia (in children and adults, but not recommended in elderly patients), rheumatoid arthritis, granulomatosis with polyangiitis, idiopathic thrombocytopenic purpura ...
Idiopathic multicentric Castleman disease (iMCD) is a subtype of Castleman disease (also known as giant lymph node hyperplasia, lymphoid hamartoma, or angiofollicular lymph node hyperplasia), a group of lymphoproliferative disorders characterized by lymph node enlargement, characteristic features on microscopic analysis of enlarged lymph node tissue, and a range of symptoms and clinical findings.
Medicare Part B (medical insurance) may cover Rituxan (rituximab) infusions. This is because medical professionals typically administer the medication in a medical setting on an outpatient basis.
Histiocytoma is a benign skin tumor that is more frequent in young dogs (<4 years), and often regresses without treatment. [ 165 ] Malignant histiocytosis ( histiocytic sarcoma ) is an aggressive cancer found primarily in certain breeds including the Bernese Mountain Dog , rottweiler , golden retriever and flat coated retriever .
CD20 is a protein that is found on the surface of B-cells and thus serves as an important target in the treatment of many B-cell malignances, including CLL. [45] Some CD20 antibodies that have been used for the treatment of CLL include: [45] Rituximab; Ofatumumab; Obinutuzumab
An example antibody for use in immunotherapy is Rituximab. Rituximab has specific use in treatment of NLPHL as it is a chimeric monoclonal antibody against the protein CD20. [18] Studies indicate Rituximab offers potential in relapsed or refractory patients, [22] and also in front-line treatment [4] especially in advanced stages. [15]
Treatment may involve one or more of the following: chemotherapy, radiation therapy, proton therapy, targeted therapy, and surgery. [ 1 ] [ 2 ] In some non-Hodgkin lymphomas, an increased amount of protein produced by the lymphoma cells causes the blood to become so thick that plasmapheresis is performed to remove the protein. [ 2 ]
Rituximab has been used with encouraging results. [14] Other medications are used to treat symptoms without influencing the nature of the disease (symptomatic treatment): Trazodone can be useful against irritability and sleep problems; Additional treatment options include plasmapheresis for severe, steroid-unresponsive relapses.