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Alosetron, sold under the brand name Lotronex among others, is a 5-HT 3 antagonist used for the management of severe diarrhea-predominant irritable bowel syndrome (IBS) in females only. It was patented in 1987 and approved for medical use in 2002. [ 2 ]
European Union, Canada, Australia Hepatotoxicity [3] Tolrestat (Alredase) 1996 Argentina, Canada, Italy, others Severe hepatotoxicity [3] Triacetyldiphenolisatin: 1971 Australia Hepatotoxicity. [3] Triazolam: 1991 France, Netherlands, Finland, Argentina, UK others Psychiatric adverse drug reactions, amnesia. [3] [66] Triparanol: 1962 France, US
Alosetron — used in the management of severe chronic diarrhea-predominant irritable bowel syndrome (IBS-D) in females not responsive to conventional therapy. Its use is restricted due to serious gastrointestinal adverse reactions, e.g. ischemic colitis and complications of constipation. [9]
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Ondansetron was approved by the U.S. Food and Drug Administration in 1991, and has since become available in several other countries, including the UK, Ireland, Australia, Canada, France and Brazil. As of 2008, ondansetron and granisetron are the only 5-HT 3 antagonists available as a generic drug in the United States.
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Although some non-selective serotonin antagonists may have a particular affinity for a specific 5-HT receptor (and thus may be listed below e.g., methysergide), they still may also possess a generalised non-selective action.