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Alosetron, sold under the brand name Lotronex among others, is a 5-HT 3 antagonist used for the management of severe diarrhea-predominant irritable bowel syndrome (IBS) in females only. It was patented in 1987 and approved for medical use in 2002. [ 2 ]
Palonosetron, sold under the brand name Aloxi, is a medication used for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). [2] [4] [5] It is a 5-HT 3 antagonist.
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Alosetron — used in the management of severe chronic diarrhea-predominant irritable bowel syndrome (IBS-D) in females not responsive to conventional therapy. Its use is restricted due to serious gastrointestinal adverse reactions, e.g. ischemic colitis and complications of constipation. [9]
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Skeletal formula of alosetron. Created using ACD/ChemSketch 12.0 and Inkscape. Optimized with vim. Date: 14 June 2011: Source: Own work, after ChemSpider 2015. Author: Fvasconcellos (talk · contribs) Permission (Reusing this file)