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It does not cause weight gain and has less hypoglycemia compared to sulfonylureas. Sitagliptin is recommended as a second-line drug (in combination with other drugs) after the combination of diet/exercise and metformin fails. [29]
In the United States, sitagliptin/metformin is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes. [5] [6]In the European Union, sitagliptin/metformin is indicated as an adjunct to diet and exercise to improve glycemic control in people with type 2 diabetes; in combination with a sulfonylurea as an adjunct to diet and exercise "in people ...
Cause an average of 2–5 kg weight gain; Increase the risk of hypoglycemia; Glyburide increases risk of hypoglycemia slightly more compared to glimepiride and glipizide; Metformin: Acts on the liver to reduce gluconeogenesis and causes a decrease in insulin resistance via increasing AMPK signalling. Associated with weight loss
However, many are associated with an infamous side effect: weight gain. Luckily, some antidepressants are less likely to cause weight gain than others. In fact, there are even some antidepressants ...
Weight fluctuations of five pounds are more are uncommon among men. Experts explain common sudden weight gain causes, what to do, and when to see a doctor. 12 Common Causes of Sudden Weight Gain
Clinical researches have shown that sitagliptin and vildagliptin do not have the side effects that tend to follow type 2 diabetes treatment, e.g. weight gain and hyperglycemia, but however, other side effects have been observed, including upper respiratory tract infections, sore throat and diarrhea. [5]
Most people know that GLP-1 receptor agonist medications like Ozempic and Wegovy can cause relatively minor side effects like nausea and diarrhea. But new research confirms that more serious ...
Metformin use is typically associated with weight loss. [69] It appears to be safe and effective in counteracting the weight gain caused by the antipsychotic medications olanzapine and clozapine. [70] [71] [72] Although modest reversal of clozapine-associated weight gain is found with metformin, primary prevention of weight gain is more ...