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The enzyme unit, or international unit for enzyme (symbol U, sometimes also IU) is a unit of enzyme's catalytic activity. [ 1 ] 1 U (μmol/min) is defined as the amount of the enzyme that catalyzes the conversion of one micro mole of substrate per minute under the specified conditions of the assay method .
In pharmacology, the international unit (IU) is a unit of measurement for the effect or biological activity of a substance, for the purpose of easier comparison across similar forms of substances. International units are used to quantify vitamins and biologics ( hormones , some medications , vaccines , blood products and similar biologically ...
In the metric system, a microgram or microgramme is a unit of mass equal to one millionth (1 × 10 −6) of a gram.The unit symbol is μg according to the International System of Units (SI); the recommended symbol in the United States and United Kingdom when communicating medical information is mcg.
See Weight for detail of mass/weight distinction and conversion. Avoirdupois is a system of mass based on a pound of 16 ounces, while Troy weight is the system of mass where 12 troy ounces equals one troy pound. The symbol g 0 is used to denote standard gravity in order to avoid confusion with the (upright) g symbol for gram.
For example, the US Adequate Intake recommendations from 1997 were 200 IU/day for infants, children, adults to age 50, and women during pregnancy or lactation, 400 IU/day for ages 51–70, and 600 IU/day for 71 and older. [168] Conversion: 1 μg (microgram) = 40 IU (international unit). [56]
The insulin unit conversion is not consistent with his molar weight 5808 Da (g/mol): Using the insulin unit definition as 0.0347 mg/IU and human insulin molar mass 5808 g/mol: 1 IU = (0.0347*10^-3 g) / (5808 g/mol) = 5.974 * 10^-9 mol. But in other sources is written, that 1 IU of insulin is 6.945 * 10^-9 mol. Where is the mistake?
Reference ranges for blood tests of plasma renin activity can be given both in mass and in international units (μIU/mL or equivalently mIU/L, improperly shown as μU/mL or U/L, confusing mcU/mL used where Greek μ not available), with the former being roughly convertible to the latter by multiplying with 11.2. [3]
Ish-Shalom et al. [69] performed a study in elderly women to compare the efficacy and safety of a daily dose of 1500 IU to a weekly dose of 10 500 IU and to a dose of 45 000 IU given every 28 days for two months. They concluded that supplementation with vitamin D can be equally achieved with daily, weekly, or monthly dosing frequencies.