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Elixir sulfanilamide was an improperly prepared sulfonamide antibiotic that caused mass poisoning in the United States in 1937. It is believed to have killed 107 people. [ 1 ] The public outcry caused by this incident and other similar disasters led to the passing of the 1938 Federal Food, Drug, and Cosmetic Act , which significantly increased ...
In 1937, S. E. Massengill Co. (a Tennessee drug company), manufactured sulfanilamide dissolved with diethylene glycol, to create a liquid alternative of this drug. The company tested the new product, Elixir sulfanilamide, for viscosity, appearance and fragrance. At the time, the food and drug laws did not require toxicological analysis before ...
Elixir sulfanilamide was formulated with diethylene glycol as a solvent. The company claimed to have been unaware of the toxicity of diethylene glycol, despite the existence of published studies describing its dangerous properties. The elixir was released with no safety testing, leading to the deaths of at least one hundred people in fifteen ...
Sulfanilamide (also spelled sulphanilamide) is a sulfonamide antibacterial drug. Chemically, it is an organic compound consisting of an aniline derivatized with a sulfonamide group. [ 1 ] Powdered sulfanilamide was used by the Allies in World War II to reduce infection rates and contributed to a dramatic reduction in mortality rates compared to ...
Spurred by public outcry from the Elixir Sulfanilamide disaster (in which 100 people were killed because under the 1906 law, “premarketing toxicity testing was not required”), congress rushed to enact a new bill. [24] Even with the Elixar disaster, the bill itself was not subject to much public awareness. [25]
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The introduction of this act was influenced by the death of more than 100 patients due to a sulfanilamide medication where diethylene glycol was used to dissolve the drug and make a liquid form. [3] See Elixir Sulfanilamide disaster. It replaced the earlier Pure Food and Drug Act of 1906.
1937 Elixir sulfanilamide incident: S. E. Massengill Company used diethylene glycol as the solvent for the antibacterial sulfanilamide, leading to the 1938 passage of the Federal Food, Drug, and Cosmetic Act. [2] [3] 1942, Nose droppers were found to be contaminated by users to the detriment of subsequent users.