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In immunology, clonal selection theory explains the functions of cells of the immune system (lymphocytes) in response to specific antigens invading the body. The concept was introduced by Australian doctor Frank Macfarlane Burnet in 1957, in an attempt to explain the great diversity of antibodies formed during initiation of the immune response .
The theory is now sometimes known as Burnet's clonal selection theory, [113] which overlooks the contributions of Ehrlich, Jerne, Talmage, and the contributions of Lederberg, who conceptualised the genetics of clonal selection. [114] Burnet's work on graft-versus-host was in collaboration with Lone Simonsen between 1960 and 1962.
Clonal Selection Pseudo code on AISWeb; CLONALG in Matlab developed by Leandro de Castro and Fernando Von Zuben; Optimization Algorithm Toolkit in Java developed by Jason Brownlee which includes the following clonal selection algorithms: Adaptive Clonal Selection (ACS), Optimization Immune Algorithm (opt-IMMALG), Optimization Immune Algorithm (opt-IA), Clonal Selection Algorithm (CLONALG ...
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[a] Clonal selection theory (CST): hematopoietic stem cells (1) differentiate and undergo genetic rearrangement to produce a population of cells possessing a wide range of pre-existing diversity with respect to antibody expression (2). Lymphocytes expressing antibodies that would lead to autoimmunity are filtered from the population (3), while ...
Clonal Selection Theory and the Rise of Molecular Immunology, Cambridge: Harvard University Press. The Immune Self: Theory or Metaphor? New York and Cambridge: Cambridge University Press, 1994 (Paperback 1996). Italian translation, L'immunologia Dell'io, Milano: McGraw Hill Libri Italia, 1999.
The doctors and nurses didn’t believe Tomisa Starr was having trouble breathing. Two years ago, Starr, 61, of Sacramento, California, was in the hospital for a spike in her blood pressure.
He made significant contributions to the clonal selection theory. [2] Career. Talmage was born to American Presbyterian missionaries in Japanese-controlled Korea.