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Alcohol flush reaction; Other names: Asian flush syndrome, Asian flush reaction, Asian glow, Asian red face glow: Facial flushing. Before (left) and after (right) drinking alcohol. A 22-year-old East Asian man who is ALDH2 heterozygous showing the reaction. [1] Specialty: Toxicology: Frequency: 36% of East Asians [2] [1] [3]
Remarkably, inhaled isopropyl alcohol can be used to provide nausea and vomiting relief. [39] [40] Alcohol intolerance and alcohol allergy, while often confused due to their overlapping symptoms, have distinct biological mechanisms. Alcohol intolerance is mainly due to genetic variations that affect the enzyme aldehyde dehydrogenase 2 (ALDH2). [24]
Ethanol is metabolized to acetaldehyde in people, which is then metabolized to acetic acid primarily by ALDH2. [1] People have various ALDH2 alleles.ALDH2*1 is a common allele (), but about 40% of people of East Asian ethnicity have one or two copies of the dominant ALDH2*2 instead, which causes ALDH2 deficiency.
In 1963, a 7-Eleven store near an Austin, Texas, university began to stay open all night for student shoppers. It was such a success that other stores in the chain adopted the 24/7 hours, and ...
The high concentration of acetaldehyde causes the alcohol flush reaction, colloquially known as the "Asian Flush". Since the alcohol flush reaction is highly uncomfortable and the possibility of hangovers is immediate and severe, people with this gene variant are less likely to become alcoholics. [16] [17]
Sober living houses (SLHs) are "alcohol- and drug-free living environments for individuals attempting to maintain abstinence from alcohol and drugs". [4] They are typically structured around 12-step programs or other recovery methodologies. Residents are often required to take drug tests and demonstrate efforts toward long-term recovery.