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These infections can include Helicobacter pylori due to this species not favouring an acid environment, leading to an increased risk of ulcers and gastric cancer risk in genetically susceptible patients. [50] PPI use in people who have received attempted H. pylori eradication may also be associated with an increased risk of gastric cancer. [51]
The United States Environmental Protection Agency defines NOAEL as 'an exposure level at which there are no statistically or biologically significant increases in the frequency or severity of adverse effects between the exposed population and its appropriate control; some effects may be produced at this level, but they are not considered as adverse, or as precursors to adverse effects. [5]
Cancer slope factors (CSF) are used to estimate the risk of cancer associated with exposure to a carcinogenic or potentially carcinogenic substance. A slope factor is an upper bound, approximating a 95% confidence limit , on the increased cancer risk from a lifetime exposure to an agent by ingestion or inhalation .
In 2022, these concerns were confirmed in a Taiwanese nationwide population study finding "significant trends of increased liver cancer risk with an increasing dose of ranitidine" (22% higher than control) and increased gastric, pancreatic, lung (26%, 35%, and 17% respectively), but "only liver cancer displayed a significant association with ...
A 31-study review found that the overall risk of pneumonia is about 1 in 4 higher among H 2 antagonist users. [ 10 ] According to a 2022 umbrella review of meta-analyses, the use of H 2 receptor antagonist is associated with pneumonia, peritonitis, necrotizing enterocolitis, Clostridioides difficile infection, liver cancer , gastric cancer ...
People who take antacids may be at greater risk for migraine attacks and severe headaches, a new study using data from more than 11,000 people suggests. The study, ...
Chemical Safety Reports are the main end point for data assessment under REACH (the European Community Regulation on chemicals and their safe use, concerning the Registration, Evaluation, Authorisation and Restriction of Chemical substances [4]) in which hazard and exposure data are considered together to assess the risk of a substance. [5]
Anti-Cancer Agents in Medicinal Chemistry is a peer-reviewed academic journal covering the disciplines of medicinal chemistry and drug design relating to chemotherapeutic agents in cancer. It is published by Bentham Science Publishers and the editor-in-chief is Simone Carradori ("G. d'Annunzio" University of Chieti-Pescara). The journal covers ...