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This is the WikiProject Chemistry/Assessment page. For further details on chemical compounds, see: Wikipedia:WikiProject Chemicals/Assessment Article assessments are tracked through the following pages:
As described above, the active form will covalently and irreversibly bind to the gastric proton pump, deactivating it. In H. pylori eradication, PPIs help by increasing the stomach pH, causing the bacterium to shift out of its coccoid form which is resistant to both acids and antibiotics. PPIs also show some weaker additional effects in ...
The journal covers developments in "medicinal chemistry and rational drug design for the discovery of anti-cancer agents" and publishes original research reports and review papers. [ 1 ] It is related to the journal Current Medicinal Chemistry and was established in 2001 as Current Medicinal Chemistry – Anti-Cancer Agents . [ 2 ]
Cancer slope factors (CSF) are used to estimate the risk of cancer associated with exposure to a carcinogenic or potentially carcinogenic substance. A slope factor is an upper bound, approximating a 95% confidence limit , on the increased cancer risk from a lifetime exposure to an agent by ingestion or inhalation .
R-phrases (short for risk phrases) are defined in Annex III of European Union Directive 67/548/EEC: Nature of special risks attributed to dangerous substances and preparations. The list was consolidated and republished in Directive 2001/59/EC, [ 1 ] where translations into other EU languages may be found.
In 2022, these concerns were confirmed in a Taiwanese nationwide population study finding "significant trends of increased liver cancer risk with an increasing dose of ranitidine" (22% higher than control) and increased gastric, pancreatic, lung (26%, 35%, and 17% respectively), but "only liver cancer displayed a significant association with ...
Chemical Safety Reports are the main end point for data assessment under REACH (the European Community Regulation on chemicals and their safe use, concerning the Registration, Evaluation, Authorisation and Restriction of Chemical substances [4]) in which hazard and exposure data are considered together to assess the risk of a substance. [5]
The American Institute for Cancer Research (AICR) is a large American cancer research organization associated with the World Cancer Research Fund umbrella organization. As of 2024, the charity has a four-star rating from Charity Navigator , with a score of 96 out of 100.