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The 2R hypothesis saw a resurgence of interest in the 1990s for two reasons. First, gene mapping data in humans and mice revealed extensive paralogy regions - sets of genes on one chromosome related to sets of genes on another chromosome in the same species, indicative of duplication events in evolution. [9]
Many molecular biologists and population geneticists also contributed to the development of the neutral theory. [1] [11] [12] The principles of population genetics, established by J.B.S. Haldane, R.A. Fisher, and Sewall Wright, created a mathematical approach to analyzing gene frequencies that contributed to the development of Kimura's theory.
The gene is a unit of hereditary information that exists in many physical copies in the world, and which particular physical copy will be replicated and originate new copies does not matter from the gene's point of view. [20] A selfish gene could be favored by selection by producing altruism among organisms containing it.
Balancing selection refers to a number of selective processes by which multiple alleles (different versions of a gene) are actively maintained in the gene pool of a population at frequencies larger than expected from genetic drift alone. Balancing selection is rare compared to purifying selection. [1]
The evo-devo gene toolkit is the small subset of genes in an organism's genome whose products control the organism's embryonic development. Toolkit genes are central to the synthesis of molecular genetics , palaeontology , evolution and developmental biology in the science of evolutionary developmental biology (evo-devo).
Shifting balance theory aims to explain how this may be possible. The shifting balance theory is a theory of evolution proposed in 1932 by Sewall Wright , suggesting that adaptive evolution may proceed most quickly when a population divides into subpopulations with restricted gene flow .
The candidate gene approach to conducting genetic association studies focuses on associations between genetic variation within pre-specified genes of interest, and phenotypes or disease states. This is in contrast to genome-wide association studies (GWAS), which is a hypothesis-free approach that scans the entire genome for associations between ...
Gene flow is the exchange of genes between populations or species, breaking down the structure. Examples of gene flow within a species include the migration and then breeding of organisms, or the exchange of pollen. Gene transfer between species includes the formation of hybrid organisms and horizontal gene transfer. Population genetic models ...