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In October 2024, the Committee for Veterinary Medicinal Products of the European Medicines Agency adopted a positive opinion, recommending the granting of a marketing authorization for the veterinary medicinal product Duotic, Ear gel, intended for dogs. [3] The applicant for this veterinary medicinal product is Dechra Regulatory B.V. [3]
Pentosan polysulfate is being used for this osteoarthritis in Australia. When administered to racing thoroughbreds with chronic osteoarthritis (2 to 3 mg/kg, intramuscularly, once weekly for 4 weeks, then as required), pentosan polysulfate treatment improved but did not eliminate clinical signs of joint disease. [22]
No seizures were seen within 16 hours of acepromazine administration in the 36 dogs that received the drug, and the seizures abated for 1.5 to 8 hours (n=6) or did not recur (n=2) in eight of 10 dogs that were actively seizing. Excitement-induced seizures were reduced for 2 months in one dog. [17]
Most of the other contraindications are avoiding cases where a potential side effect exacerbates a pre-existing condition: for example, because oclacitinib can cause lumps or tumors, it should not be used in dogs with cancer or a history of it; [15] because it is an immune system suppressant, it should not be used in dogs with serious infections.
Gentamicin/betamethasone valerate/clotrimazole is a fixed dose combination veterinary drug, sold under the trade name Otomax. [1] It is a suspension for otic use in dogs. The active ingredients are gentamicin, betamethasone valerate and clotrimazole. This drug product is used for treatment of acute external otitis. It is also used for the ...
Octenidine dihydrochloride is active against Gram-positive and Gram-negative bacteria. [5]In vitro suspension tests with 5 minute exposure time have shown that octenidine requires lower effective concentrations than chlorhexidine to kill common bacteria like Staphylococcus aureus, Escherichia coli, Proteus mirabilis and the yeast Candida albicans.
It is normally injected intramuscularly, though can also be injected intra-articularily (directly into the joint) in horses or subcutaneously in off-label uses. [2] Giving PSGAG intra-articularily requires it to be given aseptically, [8] and is sometimes supplemented by the antibiotic amikacin to prevent infection. [1] [3] [7]
The approximate calculation for canine efficacy dose is between the range of 1.3 and 1.7 mg/kg, in conjunction with a methylcellulose suspending agent. Based on the calculations from the comparisons of binding affinity of grapiprant to the EP4 receptors of dogs, rats, and humans, the study of plasma and serum protein binding determinations, the ...