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Brunner syndrome is a rare genetic disorder associated with a mutation in the MAOA gene. It is characterized by lower than average IQ (typically about 85), problematic impulsive behavior (such as pyromania, hypersexuality and violence), sleep disorders and mood swings. [1] [2] It was identified in fourteen males from one family in 1993.
A dysfunctional MAOA gene has been correlated with increased aggression levels in mice, [60] [61] and has been correlated with heightened levels of aggression in humans. [62] In mice, a dysfunctional MAOA gene is created through insertional mutagenesis (called 'Tg8'). [60] Tg8 is a transgenic mouse strain that lacks functional MAO-A enzymatic ...
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Rare mutations in the gene are associated with Brunner syndrome. [medical citation needed] A study based on the Dunedin cohort concluded that maltreated children with a low-activity polymorphism in the promoter region of the MAO-A gene were more likely to develop antisocial conduct disorders than maltreated children with the high-activity ...
Massages, acupuncture and herbal supplements -- self-care measures often considered a luxury for even humans -- are being increasingly given to dogs to help them live longer, according to pet experts.
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4129 109731 Ensembl ENSG00000069535 ENSMUSG00000040147 UniProt P27338 Q8BW75 RefSeq (mRNA) NM_000898 NM_172778 RefSeq (protein) NP_000889 NP_766366 Location (UCSC) Chr X: 43.77 – 43.88 Mb Chr X: 16.58 – 16.68 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Monoamine oxidase B (MAO-B) is an enzyme that in humans is encoded by the MAOB gene. The protein encoded by this gene belongs ...
The FDA has approved two new treatments for sickle-cell anemia, but much remains unknown.