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The duration of action of a single oral dose is longer than the half-life and may be up to 12 hours if the single dose is high enough (e.g., 80 mg). [72] Effective plasma concentrations are between 10 and 100 mg/L. [ citation needed ] Toxic levels are associated with plasma concentrations above 2000 mg/L. [ citation needed ]
Estradiol valerate by intramuscular injection is usually used at a dosage of 10 to 20 mg every 4 weeks in the treatment of menopausal symptoms and hypoestrogenism due to hypogonadism, castration, or primary ovarian failure in women. [13] In the past, it was used at even higher doses of 10 to 40 every 1 to 4 weeks for estrogen replacement. [36]
For instance, the half life of a 500 mg tablet is 4–6 hours rather than 3–4 hours for a 200 mg tablet. [6] The drug has high bioavailability but about 20% is lost due to first-pass metabolism. [6] Rivonavir capsules are not absorbed as quickly as Ritonavir tablets and may exhibit different bioavailability. [8]
It is often expressed in terms of mg-min/m 3. ICt 50 is the dose that will cause incapacitation rather than death. These measures are commonly used to indicate the comparative efficacy of chemical warfare agents, and dosages are typically qualified by rates of breathing (e.g., resting = 10 L/min) for inhalation, or degree of clothing for skin ...
An easy way to calculate log 2 n on calculators that do not have a log 2 function is to use the natural logarithm (ln) or the common logarithm (log or log 10) functions, which are found on most scientific calculators. To change the logarithm base to 2 from e, 10, or any other base b, one can use the formulae: [50] [53]