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In this diagram of a duplicated chromosome, (2) identifies the centromere—the region that joins the two sister chromatids, or each half of the chromosome. In prophase of mitosis, specialized regions on centromeres called kinetochores attach chromosomes to spindle fibers. The centromere links a pair of sister chromatids together during cell ...
This chromosomal change deletes the region of chromosome 15 that includes the UBE3A gene. Because the copy of the UBE3A gene inherited from a person's father (the paternal copy) is normally inactive in the brain, a deletion in the maternal chromosome 15 results in no active copies of the UBE3A gene in the brain.
Brain at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (view tree for regions of the brain) BrainMaps.org; BrainInfo (University of Washington) "Brain Anatomy and How the Brain Works". Johns Hopkins Medicine. 14 July 2021. "Brain Map". Queensland Health. 12 July 2022.
Centromere protein A, also known as CENPA, is a protein which in humans is encoded by the CENPA gene. [5] CENPA is a histone H3 variant which is the critical factor determining the kinetochore position(s) on each chromosome [ 6 ] in most eukaryotes including humans.
Raichle coined the term "default mode" in 2001 to describe resting state brain function; [19] the concept rapidly became a central theme in neuroscience. [20] Around this time the idea was developed that this network of brain areas is involved in internally directed thoughts and is suspended during specific goal-directed behaviors.
Once homologs pair, cohesins at the centromere regions help maintain their cohesion in the early stages of meiosis, ensuring the chromosomes remain together until the proper time for segregation. The assembly of the SC complex relies on two cohesin complexes: one essential for interhomolog interactions and another necessary for sister chromatid ...
Studies suggest that neocentromeres are ultimately formed from epigenetic processes, rather than from changes in DNA sequence. [7] There is a general consensus that neocentromeres result from an attempt to fix chromosomes that lack a conventional centromere, through chromosome rearrangements.
Some regions of chromatin are very densely packed with fibers that display a condition comparable to that of the chromosome at mitosis. Heterochromatin is generally clonally inherited; when a cell divides, the two daughter cells typically contain heterochromatin within the same regions of DNA, resulting in epigenetic inheritance .