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The medication midodrine, an α 1-adrenergic receptor agonsit, can benefit people with orthostatic hypotension, [33] [35] The main side effect is piloerection ("goose bumps"). [35] Fludrocortisone is also used, although based on more limited evidence.
Midodrine, sold under the brand names ProAmatine and Orvaten among others, is a vasopressor or antihypotensive medication used to treat orthostatic hypotension (low blood pressure when standing) and urinary incontinence. [3] [5] [1] It is taken by mouth. [3] [1]
Orthostatic syncope refers to syncope resulting from a postural decrease in blood pressure, termed orthostatic hypotension. [1]Orthostatic hypotension occurs when there is a persistent reduction in blood pressure of at least 20mmHg systolic or 10mmHg diastolic within three minutes of standing or being upright to 60 degrees on the head-up tilt table.
Ampreloxetine (INN Tooltip International Nonproprietary Name, USAN Tooltip United States Adopted Name; developmental code name TD-9855) is a selective norepinephrine reuptake inhibitor (NRI) which is under development for the treatment of symptomatic neurogenic orthostatic hypotension (NOH).
For hypotension, it is specifically used in the treatment of neurogenic orthostatic hypotension (NOH) in dopamine β-hydroxylase deficiency, [7] as well as NOH associated with multiple system atrophy (MSA), [9] familial amyloid polyneuropathy (FAP), and pure autonomic failure (PAF). [10]
By reducing alpha-1-adrenergic activity of the blood vessels, these drugs may cause hypotension (low blood pressure) and interrupt the baroreflex response. In doing so, they may cause dizziness, lightheadedness, or fainting when rising from a lying or sitting posture (known as orthostatic hypotension or postural hypotension). For this reason ...