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TRIzol reagent contains guanidinium thiocyanate and phenol.. TRIzol is a widely used [1] chemical solution used in the extraction of DNA, RNA, and proteins from cells. The solution was initially used and published by Piotr Chomczyński and Nicoletta Sacchi in 1987.
A triazole is a heterocyclic compound featuring a five-membered ring of two carbon atoms and three nitrogen atoms with molecular formula C 2 H 3 N 3.Triazoles exhibit substantial isomerism, depending on the positioning of the nitrogen atoms within the ring.
Guanidinium thiocyanate (GTC) or guanidinium isothiocyanate (GITC) is a chemical compound used as a general protein denaturant, being a chaotropic agent, although it is most commonly used as a nucleic acid protector in the extraction of DNA and RNA from cells. [1] GITC may also be recognized as guanidine thiocyanate.
Other denaturing chemicals such as 2-mercaptoethanol and sarcosine may also be used. The major downside is that phenol and chloroform are both hazardous and inconvenient materials, and the extraction is often laborious, so in recent years many companies now offer alternative ways to isolate RNA.
1,2,4-Triazole (as ligand in coordination compounds, Htrz abbreviation is sometimes used) is one of a pair of isomeric chemical compounds with molecular formula C 2 H 3 N 3, called triazoles, which have a five-membered ring of two carbon atoms and three nitrogen atoms. 1,2,4-Triazole and its derivatives find use in a wide variety of applications.
Chemicals which can be used as weapons, or used in their manufacture, but which have no, or almost no, legitimate applications as well are listed in Schedule 1, whilst Schedule 2 is used for chemicals which have legitimate small-scale applications. The use of Schedule 1, 2, or 3 chemicals as weapons is banned by the Convention.
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