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By unraveling the mysteries of ovarian aging (which reaches a zenith in menopause), we can better understand what role our ovaries play in our overall health, wellness, and lifespan.“The ovaries ...
Once the ovaries stop releasing eggs for 12 consecutive months, typically between ages 45 and 55 (aka menopause), women may see a dramatic increase in their risk of cardiovascular disease ...
“The ovaries are central to reproduction, but they also play a critical role in overall health, producing hormones that regulate numerous systems, including the heart, bones, and brain.”
The primary role of the follicle is oocyte support. From the whole pool of follicles a woman is born with, only 0.1% of them will rise ovulation, whereas 99.9% will break down (in a process called follicular atresia). From birth, the ovaries of the human female contain many immature, primordial follicles.
Menopause occurs because of the sharp decrease of estradiol and progesterone production by the ovaries. After menopause, estrogen continues to be produced mostly by aromatase in fat tissues and is produced in small amounts in many other tissues such as ovaries, bone, blood vessels, and the brain where it acts locally. [62]
Upon menopause in females, production of estrogens by the ovaries stops and estradiol levels decrease to very low levels. In addition to its role as a natural hormone, estradiol is used as a medication , for instance in menopausal hormone therapy and feminizing hormone therapy for transgender women ; for information on estradiol as a medication ...