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2. Treatment-resistant depression - Wikipedia

   en.wikipedia.org/wiki/Treatment-resistant_depression

   Ketamine has been tested as a rapid-acting antidepressant [13] for treatment-resistant depression in bipolar disorder, and major depressive disorder. [14] Spravato, a nasal spray form of esketamine, was approved by the FDA in 2019 for use in treatment-resistant depression when combined with an oral antidepressant. [15] [16]

3. Management of depression - Wikipedia

   en.wikipedia.org/wiki/Management_of_depression

   The risk factors [110] for treatment resistant depression are: the duration of the episode of depression, severity of the episode, if bipolar, lack of improvement in symptoms within the first couple of treatment weeks, anxious or avoidant and borderline comorbidity and old age. Treatment resistant depression is best handled with a combination ...

4. STAR*D - Wikipedia

   en.wikipedia.org/wiki/STAR*D

   Sequenced Treatment Alternatives to Relieve Depression (STAR*D) was a collaborative study on the treatment of depression, funded by the National Institute of Mental Health. Its main focus was on the treatment of depression in patients where the first prescribed antidepressant proved inadequate.

5. Breakthrough antidepressants with fewer side effects could ...

   www.aol.com/finance/breakthrough-antidepressants...

   The FDA approved Johnson & Johnson’s drug for treatment-resistant depression in 2019. Esketamine is derived from a pediatric anesthetic called ketamine. Through research pioneered at Yale ...

6. History of electroconvulsive therapy in the United States

   en.wikipedia.org/wiki/History_of...

   Antidepressants are considered a first line treatment for depression. While these medications are assessable to most, and effective enough to reduce clinical manifestations and increase quality of life for many suffering from depression, they are often not effective for severe depression and they come with a large array of side effects.

7. What you need to know about 'treatment-resistant' depression ...

   www.aol.com/news/know-treatment-resistant...

   In the immediate aftermath of a high-profile suicide of a beloved celebrity like Naomi Judd, calls to suicide-prevention hotlines tend to increase.