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2. Treatment-resistant depression - Wikipedia

   en.wikipedia.org/wiki/Treatment-resistant_depression

   Ketamine has been tested as a rapid-acting antidepressant [22] for treatment-resistant depression in bipolar disorder, and major depressive disorder. [23] Spravato, a nasal spray form of esketamine, was approved by the FDA in 2019 for use in treatment-resistant depression when combined with an oral antidepressant. [24] [25]

3. Switching Antidepressants: Safety, Side Effects & Other ... - AOL

   www.aol.com/switching-antidepressants-safety...

   Research shows that approximately one-third of people with depression have treatment-resistant depression (TRD). With TRD, depression doesn’t always improve through standard treatments, like ...

4. Breakthrough antidepressants with fewer side effects could ...

   www.aol.com/finance/breakthrough-antidepressants...

   The FDA approved Johnson & Johnson’s drug for treatment-resistant depression in 2019. Esketamine is derived from a pediatric anesthetic called ketamine. Through research pioneered at Yale ...

5. Management of depression - Wikipedia

   en.wikipedia.org/wiki/Management_of_depression

   The risk factors [110] for treatment resistant depression are: the duration of the episode of depression, severity of the episode, if bipolar, lack of improvement in symptoms within the first couple of treatment weeks, anxious or avoidant and borderline comorbidity and old age. Treatment resistant depression is best handled with a combination ...

6. List of investigational antidepressants - Wikipedia

   en.wikipedia.org/wiki/List_of_investigational...

   This is a list of investigational antidepressants, or drugs that are currently under development for clinical use in the treatment of depression but are not yet approved. Specific indications include major depressive disorder, treatment-resistant depression, dysthymia, bipolar depression, and postpartum depression, among others.

7. Researchers Identified 6 'Biotypes' Of Depression - AOL

   www.aol.com/lifestyle/researchers-identified-6...

   We asked how common treatment-resistant depression is. “A study led by researchers at UT Southwestern suggests that as many as 1 in 3 treatment-seeking outpatients may have treatment-resistant ...