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These cells are the primary output neurons of the cerebellar cortex and cerebellum. The second germinal zone (cellular birthplace) is known as the rhombic lip, neurons then move by human embryonic week 27 to the external granular layer. This layer of cells—found on the exterior of the cerebellum—produces the granule neurons.
Because of its large number of tiny granule cells, the cerebellum contains more neurons than the total from the rest of the brain, but takes up only 10% of the total brain volume. [11] The number of neurons in the cerebellum is related to the number of neurons in the neocortex. There are about 3.6 times as many neurons in the cerebellum as in ...
They develop in the cerebellar primordium that covers the fourth ventricle and below a fissure-like region called the isthmus of the developing brain. Purkinje cells migrate toward the outer surface of the cerebellar cortex and form the Purkinje cell layer. Purkinje cells are born during the earliest stages of cerebellar neurogenesis.
There are four paired deep cerebellar nuclei embedded in the white matter centre of the cerebellum. The nuclei are the fastigial , globose , emboliform , and dentate nuclei. In lower mammals the emboliform nucleus appears to be continuous with the globose nucleus, and these are known together as the interposed nucleus .
Some neurons of the ventral spinocerebellar tract instead form synapses with neurons in layer VII of L4-S3. Most of these fibers cross over to the contralateral lateral funiculus via the anterior white commissure and through the superior cerebellar peduncle. The fibers then often cross over again within the cerebellum to end on the ipsilateral ...
He wrote Cerebri Anatome (Latin: Anatomy of the brain) [c] in 1664, followed by Cerebral Pathology in 1667. In these he described the structure of the cerebellum, the ventricles, the cerebral hemispheres, the brainstem, and the cranial nerves, studied its blood supply; and proposed functions associated with different areas of the brain. [233]
Pontocerebellar fibers are the sole efferent pathway of the pontine nuclei. The fibers mostly decussate within the pons to pass through the (contralateral) middle cerebellar peduncle to terminate in the contralateral cerebellum as mossy fibers; they form terminal synapses in the cerebellar cortex, but also issue collaterals to the cerebellar nuclei.
The entire pathway begins and ends in the cerebral cortex, and its entire course is the following: [2] (Motor and sensory areas of) cerebral cortex → corticopontine fibers → (ipsilateral) nuclei pontis (synapse) → pontocerebellar fibers (decussation within pons) → middle cerebellar peduncle → (contralateral) (cerebellar cortex and (collaterals) dentate nucleus of) posterior lobe of ...