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Gender: Plasma concentrations are generally higher in women than in men, but there is no clinically significant difference in the extent of LDL reduction between men and women. [4] Kidney impairment: Kidney disease has no statistically significant influence on plasma concentrations of atorvastatin and dose adjustment considerations should only ...
Nephrotoxicity is toxicity in the kidneys.It is a poisonous effect of some substances, both toxic chemicals and medications, on kidney function. [1] There are various forms, [2] and some drugs may affect kidney function in more than one way.
Media reporting on statins is often negative, and patient leaflets inform patients that rare but potentially serious muscle problems can occur during statin treatment. These create expectations of harm. Nocebo symptoms are real and bothersome and are a major barrier to treatment.
AKI - the other main type of kidney disease - can be caused by dehydration, blood loss, urinary tract obstructions such as kidney stones or blood clots, low blood pressure, or heart disease. It ...
URAT1 is the central mediator in the transport of uric acid from the kidney into the blood. In some persons with loss-of-function mutations of URAT1, the uricosurics benzbromarone and losartan had no effect, suggesting these drugs act on URAT1 in vivo. [1] Thus, uricosuric drugs may be candidates for management in a personalized medicine model.
“Vitamin D can interact with statins, steroids and thiazide diuretics,” Zumpano says. ... However, taking too much vitamin D can cause side effects or health issues. ... Kidney stones "In ...
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