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About 60% of the metronidazole is metabolized by oxidation to the main metabolite hydroxymetronidazole and a carboxylic acid derivative, and by glucuronidation. The metabolites show antibiotic and antiprotozoal activity in vitro. [61] Metronidazole and its metabolites are mainly excreted via the kidneys (77%) and to a lesser extent via the ...
Urinary tract infection in pediatric patients is a significant clinical issue, affecting approximately 7% of fevered infants and children. [43] If left untreated, the infection can ascend from the bladder to the kidneys, resulting in acute pyelonephritis, which leads to hypertension , kidney scarring , and end-stage kidney disease .
Trichomoniasis: Oral treatment with either metronidazole or tinidazole. [8] "Sexual partner(s) should be treated simultaneously. Sexual partner(s) should be treated simultaneously. Patients should be advised to avoid sexual intercourse for at least 1 week and until they and their partner(s) have completed treatment and follow-up."
Trichomoniasis is a common STI that is caused by infection with a protozoan parasite called Trichomonas vaginalis. [70] Trichomoniasis affects both women and men, but symptoms are more common in women. [71] Most patients are treated with an antibiotic called metronidazole, which is very effective. [72]
STIs like chlamydia, gonorrhea, trichomoniasis, and Mycoplasma genitalium can all cause inflammation and irritation of the vagina and cervix, Dr. Bukowski notes. Herpes blisters can cause ulcers ...
For 95–97% of cases, infection is resolved after one dose of metronidazole. [26] [35] Studies suggest that 4–5% of trichomonas cases are resistant to metronidazole, which may account for some "repeat" cases. [33] [9] Without treatment, trichomoniasis can persist for months to years in women, and is thought to improve without treatment in ...