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Histamine, a biogenic amine, involves many physiological functions, including the immune response, gastric acid secretion, and neuromodulation. However, its rapid metabolism makes it challenging to measure histamine levels directly in plasma. [46]
Histamine N-methyltransferase is encoded by a single gene, called HNMT, which has been mapped to chromosome 2 in humans. [5]Three transcript variants have been identified for this gene in humans, which produce different protein isoforms [6] [5] due to alternative splicing, which allows a single gene to code for multiple proteins by including or excluding particular exons of a gene in the final ...
NMH may have some modulatory effects on histamine signalling, but it is unlikely to cause significant allergic or inflammatory reactions by itself. NMH may also serve as a feedback mechanism to regulate histamine levels and prevent excessive histamine release. [3]
Cold air also causes more histamine production, which is what the body makes during an allergic reaction. Histamine can lead to breathing issues such as wheezing and difficulty breathing.
Also called an intradermal test, this skin end point titration (SET) uses an intradermal injection of allergens at increasing concentrations to measure allergic response. [9] To prevent a severe allergic reaction, the test is started with a very dilute solution.
DAO levels in the blood circulation increase vastly in pregnant women suggesting a protective mechanism against adverse histamine. [12] Histamine is a potent vasodilator and can cause uterine contractions, which can lead to premature labor. DAO in the placenta breaks down histamine to prevent its accumulation and maintain a healthy pregnancy.
Histamine, a biogenic amine found in various food products, is frequently implicated as a potential instigator of a range of health issues. [1] These issues are often collectively referred to under the umbrella term "histamine intolerance", [1] formulated drawing parallels to "lactose intolerance", a condition resulting from lactase enzyme deficiency.
The enzyme histidine decarboxylase (EC 4.1.1.22, HDC) is transcribed on chromosome 15, region q21.1-21.2, and catalyzes the decarboxylation of histidine to form histamine.In mammals, histamine is an important biogenic amine with regulatory roles in neurotransmission, gastric acid secretion and immune response.