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Sensitization is a non-associative learning process in which repeated administration of a stimulus results in the progressive amplification of a response. [1] Sensitization often is characterized by an enhancement of response to a whole class of stimuli in addition to the one that is repeated.
In immunology, the term sensitization is used for the following concepts: [1] [2] [3] [4] [5]. Immunization by inducing an adaptive response in the immune system. [1 ...
Reverse tolerance or drug sensitization is a pharmacological phenomenon describing subjects' increased reaction (positive or negative) to a drug following its repeated use. [4] Not all drugs are subject to reverse tolerance. This is the opposite of drug tolerance, in which the effect or the subject's reaction decreases following its repeated ...
The murine local lymph node assay (LLNA) is an in vivo test for skin sensitisation.. LLNA has largely superseded the guinea pig maximisation test and the Buehler test.It is considered more scientific and less cruel (lower number of animals; less suffering) and has found broad scientific and regulatory acceptance.
Central pain syndrome, also known as central neuropathic pain, [1] is a neurological condition consisting of constant moderate to severe pain due to damage to the central nervous system (CNS) which causes a sensitization of the pain system. [2] [3] The extent of pain and the areas affected are related to the cause of the injury. [4]
Nociplastic pain is a longterm complex pain, one of three mechanisms of pain, defined by the International Association for the Study of Pain as "pain that arises from altered nociception despite no clear evidence of actual or threatened tissue damage causing the activation of peripheral nociceptors or evidence for disease or lesion of the somatosensory system causing the pain". [2]
For example, if America’s trading partners imposed severe retaliatory tariffs, as they’ve threatened, it would hurt exports from the U.S. and cause a slowdown.
Nociceptor sensitivity is modulated by a large variety of mediators in the extracellular space, such as toxic and inflammatory molecules. [15] [4] Peripheral sensitization represents a form of functional plasticity of the nociceptor. The nociceptor can change from being simply a noxious stimulus detector to a detector of non-noxious stimuli.