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Tocilizumab, sold under the brand name Actemra among others, is an immunosuppressive drug, used for the treatment of rheumatoid arthritis, systemic juvenile idiopathic arthritis, polyarticular juvenile idiopathic arthritis, giant cell arteritis, cytokine release syndrome, COVID‑19, and systemic sclerosis-associated interstitial lung disease (SSc-ILD).
Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. [1] It typically results in warm, swollen, and painful joints. [1] Pain and stiffness often worsen following rest. [1] Most commonly, the wrist and hands are involved, with the same joints typically involved on both sides of the body. [1]
Autoinflammatory diseases (AIDs) are a group of rare disorders caused by dysfunction of the innate immune system.These responses are characterized by periodic or chronic systemic inflammation, usually without the involvement of adaptive immunity.
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The superior cluneal nerves are pure sensory nerves that innervate the skin of the upper part of the buttocks.They are the terminal ends of the L1-L3 spinal nerve dorsal rami lateral branches.
A positive test is indicated by patient report of a reproduction of vertigo and clinician observation of nystagmus (involuntary eye movement).. For some patients, this maneuver may be contraindicated, and a modification may be needed that also targets the posterior semicircular canal.
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