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FAD is an aromatic ring system, whereas FADH 2 is not. [12] This means that FADH 2 is significantly higher in energy, without the stabilization through resonance that the aromatic structure provides. FADH 2 is an energy-carrying molecule, because, once oxidized it regains aromaticity and releases the energy represented by this stabilization ...
The electron transport chain oxidizes coenzymes NADH and FADH2. Protein synthesis makes use of mitochondrial DNA, RNA, and tRNA. [5] Regulation of processes makes use of ions (Ca 2+ /K + /Mg +). [6] Additional metabolites present in the matrix are CO 2, H 2 O, O 2, ATP, ADP, and P i. [1]
Translation is one of the key energy consumers in cells, hence it is strictly regulated. Numerous mechanisms have evolved that control and regulate translation in eukaryotes as well as prokaryotes. Regulation of translation can impact the global rate of protein synthesis which is closely coupled to the metabolic and proliferative state of a cell.
In eukaryotes, NADH is the most important electron donor. The associated electron transport chain is NADH → Complex I → Q → Complex III → cytochrome c → Complex IV → O 2 where Complexes I, III and IV are proton pumps, while Q and cytochrome c are mobile electron carriers. The electron acceptor for this process is molecular oxygen.
Found in all living cells, NAD is called a dinucleotide because it consists of two nucleotides joined through their phosphate groups. One nucleotide contains an adenine nucleobase and the other, nicotinamide. NAD exists in two forms: an oxidized and reduced form, abbreviated as NAD + and NADH (H for hydrogen), respectively.
The net effect of the malate–aspartate shuttle is purely redox: NADH in the cytosol is oxidized to NAD +, and NAD + in the matrix is reduced to NADH. The NAD + in the cytosol can then be reduced again by another round of glycolysis, and the NADH in the matrix can be used to pass electrons to the electron transport chain so ATP can be synthesized.
During translation, genetic material called mRNA is read by ribosomes to generate a protein polypeptide chain. [53] This process requires transfer RNA (tRNA) which serves as an adaptor by binding amino acids on one end and interacting with mRNA at the other end; the latter pairing between the tRNA and mRNA ensures that the correct amino acid is ...
The cofactors NAD + and FAD are sometimes reduced during this process to form NADH and FADH 2, which drive the creation of ATP in other processes. [15] A molecule of NADH can produce 1.5–2.5 molecules of ATP, whereas a molecule of FADH 2 yields 1.5 molecules of ATP.