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CSF/serum albumin ratio is a test performed to compare the levels of albumin in the cerebrospinal fluid and the serum. It is useful as a measure of the integrity of the blood–brain barrier . [ 1 ] [ 2 ] [ 3 ]
The serum-ascites albumin gradient or gap (SAAG) is a calculation used in medicine to help determine the cause of ascites. [1] The SAAG may be a better discriminant than the older method of classifying ascites fluid as a transudate versus exudate.
CSF albumin is a measurement used to determine the levels of albumin in cerebrospinal fluid. [1]A closely related test, CSF total protein is a measurement used to determine the levels of protein in cerebrospinal fluid.
Human serum albumin is encoded by the ALB gene. [2] [3] [4] Other mammalian forms, such as bovine serum albumin, are chemically similar. Serum albumin is produced by the liver, occurs dissolved in blood plasma and is the most abundant blood protein in mammals.
Albumin is a family of globular proteins, the most common of which are the serum albumins.All of the proteins of the albumin family are water-soluble, moderately soluble in concentrated salt solutions, and experience heat denaturation.
Serum total protein, also known as total protein, is a clinical chemistry parameter representing the concentration of protein in serum. [1] Serum contains many proteins including serum albumin, a variety of globulins, and many others.
In alcoholic liver disease, the mean ratio is 1.45, and mean ratio is 1.33 in post necrotic liver cirrhosis. Ratio is greater than 1.17 in viral cirrhosis, greater than 2.0 in alcoholic hepatitis, and 0.9 in non-alcoholic hepatitis. Ratio is greater than 4.5 in Wilson disease or hyperthyroidism. [6]
Cold insoluble globulin forms a band here which is not seen in plasma because it is precipitated by heparin. There are low levels in inflammation and high levels in pregnancy. [citation needed] Beta lipoprotein forms an irregular crenated band in this zone.