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In the UK, Actavis marketed promethazine hydrochloride under the Sominex name. [41] It was available at least as early as 1985 as an OTC hypnotic. [42] Actavis also marketed a product by the name of Sominex Herbal, an herbal sleep aid with three natural active ingredients: hops, valerian, and passion flower extracts. [43]
Because of the potential for more severe side effects, this drug is on the list to avoid in the elderly. [22] In many countries (including the US and UK), promethazine is contraindicated in children less than two years of age, and strongly cautioned against in children between two and six, due to problems with respiratory depression and sleep ...
Together with scopolamine, it was the main ingredient in Sominex, Nytol, and Sleep-Eze. It also provided the sedative component of Excedrin PM. [ 2 ] All of these products were reformulated in the late 1970s [ 3 ] when methapyrilene was demonstrated to cause liver cancer in rats when given chronically.
It contains the following active ingredients (15 mL is one tablespoon, half the recommended adult dose): Acetaminophen (500 mg/15 mL) (pain reliever/fever reducer) Dextromethorphan (15 mg/15 mL) (cough suppressant) Doxylamine succinate (6.25 mg/15 mL) (antihistamine/hypnotic) Pseudoephedrine (30 mg/15 mL) (nasal decongestant)
1 Adverse effects. 2 References. Toggle the table of contents. ... The intended use of the drug is relieve pain specifically when going to sleep. [2] Adverse effects
Doxylamine and other first-generation antihistamines are the most widely used sleep medications in the world. [6] Typical side effects of doxylamine (at recommended doses) include dizziness, drowsiness, grogginess, and dry mouth, among others. [7] [4] As an antihistamine, doxylamine is an inverse agonist of the histamine H 1 receptor.