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Antiretroviral drugs for HIV. Antiviral drugs are a class of medication used for treating viral infections. [1] Most antivirals target specific viruses, while a broad-spectrum antiviral is effective against a wide range of viruses. [2] Antiviral drugs are a class of antimicrobials, a larger group which also includes antibiotic (also termed ...
Infectious diseases, gastroenterology. Viral hepatitis is liver inflammation due to a viral infection. [1][2] It may present in acute form as a recent infection with relatively rapid onset, or in chronic form, typically progressing from a long-lasting asymptomatic condition up to a decompensated hepatic disease and hepatocellular carcinoma (HCC).
Nonstructural protein 5A (NS5A) inhibitors are direct acting antiviral agents (DAAs) that target viral proteins, and their development was a culmination of increased understanding of the viral life cycle combined with advances in drug discovery technology. [1][2] However, their mechanism of action is complex and not fully understood. [2]
In a nutshell, “hepatitis C is a virus that infects the liver, causing inflammation and scarring of the organ,” says K. V. Narayanan Menon, MD, the medical director of liver transplantation at ...
Telaprevir (VX-950), marketed under the brand names Incivek and Incivo, is a pharmaceutical drug for the treatment of hepatitis C co-developed by Vertex Pharmaceuticals and Johnson & Johnson. It is a member of a class of antiviral drugs known as protease inhibitors. [3] Specifically, telaprevir inhibits the hepatitis C viral enzyme NS3/4A ...
The second trial compared twelve weeks of treatment with the combination versus treatment with the previously approved drugs sofosbuvir and velpatasvir in adults with genotypes 1, 2, or 3 who had previously failed treatment with sofosbuvir but not an NS5A inhibitor drug. [6]
Boceprevir (INN, trade name Victrelis) is a protease inhibitor used to treat hepatitis caused by hepatitis C virus (HCV) genotype 1. [2][3] It binds to the HCV nonstructural protein 3 active site. [4] It was initially developed by Schering-Plough, [5] then by Merck after it acquired Schering in 2009.
Mayo Clinic’s Florida campus in Jacksonville will receive $12 million and manage the distribution of the remaining grant to its collaborators in the study. The experimental drug is called ...
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