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Acitretin is a metabolite of etretinate, which was used prior to the introduction of acitretin. Etretinate was discontinued because it had a narrow therapeutic index as well as a long elimination half-life (t 1/2 = 120 days), making dosing difficult. In contrast, acitretin's half-life is approximately 2 days.
The WHO Model List of Essential Medicines for Children (aka Essential Medicines List for Children [1] or EMLc [1]), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe in children up to twelve years of age to meet the most important needs in a health system.
Etretinate has been replaced by acitretin, the free acid (without the ethyl ester). While acitretin is less lipophilic and has a half-life of only 50 hours, it is partly metabolized to etretinate in the body, [ 2 ] so that it is still a long-acting teratogen and pregnancy is prohibited for two years after therapy.
There is currently no federal guidance on how much caffeine is safe for kids and teens, although the Food and Drug Administration says that most healthy adults can safely have up to 400 milligrams ...
In Detroit, where temperatures dropped into the lower teens (about minus 11 Celsius), two children under age 10 likely died from exposure to the cold after they were discovered with other family ...
Isotretinoin is the only non-psychiatric drug on the FDA's top 10 list of drugs associated with depression [58] [63] and is also within the top 10 for suicide attempts. [64] A black box warning for suicide, depression, and psychosis has been present on isotretinoin's packaging in the United States since 2005. [63]
Calls to poison control centers about children age 5 and younger consuming edibles containing tetrahydrocannabinol, or THC, rose from 207 to 3,054 in four years — a 1,375% increase, according to ...
Alitretinoin is a form of vitamin A. Alitretinoin has been administered in oncological clinical studies at dosages of more than 10-times of the therapeutic dosage given for chronic hand eczema. The adverse effects observed were consistent with retinoid toxicity, and included severe headache, diarrhoea, facial flushing and hypertriglyceridemia .
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