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Acitretin is a metabolite of etretinate, which was used prior to the introduction of acitretin. Etretinate was discontinued because it had a narrow therapeutic index as well as a long elimination half-life (t 1/2 = 120 days), making dosing difficult. In contrast, acitretin's half-life is approximately 2 days.
Executive Order 14187, titled "Protecting Children from Chemical and Surgical Mutilation", is an executive order issued by Donald Trump on January 28, 2025. [1] The order acts to prevent gender affirming care for Americans under 19 years old by withholding federal funding and directing agencies to take a variety of steps to prevent surgeries, hormone therapy, puberty blockers and other gender ...
The selection and use of essential medicines. Twentieth report of the WHO Expert Committee 2015 (including 19th WHO Model List of Essential Medicines and 5th WHO Model List of Essential Medicines for Children). Geneva: World Health Organization. hdl: 10665/189763. ISBN 9789240694941. ISSN 0512-3054. WHO technical report series; no. 994.
Etretinate has been replaced by acitretin, the free acid (without the ethyl ester). While acitretin is less lipophilic and has a half-life of only 50 hours, it is partly metabolized to etretinate in the body, [ 2 ] so that it is still a long-acting teratogen and pregnancy is prohibited for two years after therapy.
Teens will only be matched with highly rated and experienced drivers, the company says, noting that drivers have to undergo a "thorough background check" and are re-screened annually.
Bexarotene, sold under the brand Targretin, is an antineoplastic (anti-cancer) agent used for the treatment of cutaneous T cell lymphoma (CTCL). [4] It is a third-generation retinoid. [5] It was approved by the U.S. Food and Drug Administration (FDA) in December 1999, and the European Medicines Agency (EMA) in March 2001.
There is currently no federal guidance on how much caffeine is safe for kids and teens, although the Food and Drug Administration says that most healthy adults can safely have up to 400 milligrams ...
Finally, Levkoff points out that if your reaction to finding this toy is strongly negative, it’s important that you ask yourself why that may be the case before addressing it with your teen.