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Propofol [7] is the active component of an intravenous anesthetic formulation used for induction and maintenance of general anesthesia. It is chemically termed 2,6-diisopropylphenol. It is chemically termed 2,6-diisopropylphenol.
Most propofol is conjugated in the liver with pharmacologically inactive metabolites. [33] Although it has a long terminal elimination half-life of 4 to 30 hours, plasma concentrations remain low after the typical induction dose. [33]
Commonly used intravenous induction agents include propofol, sodium thiopental, etomidate, methohexital, and ketamine. Inhalational anaesthesia may be chosen when intravenous access is difficult to obtain (e.g., children), when difficulty maintaining the airway is anticipated, or when the patient prefers it.
Ciprofol (also known as cipepofol, or HSK3486) is a novel 2,6-disubstituted phenol derivative that is used for the intravenous induction of general anesthesia. [1] [2] A short-acting and highly selective γ-aminobutyric acid agonist, [3] ciprofol is 4–6 times more potent than other phenol derivatives such as propofol or fospropofol.
The MAC is the percentage dose of anesthetic that will prevent a response to painful stimulus in 50% of subjects. The higher the MAC, generally, the less potent the anesthetic. Syringes prepared with medications that are expected to be used during an operation under general anesthesia maintained by sevoflurane gas: – Propofol, a hypnotic
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Propofol – It is a highly lipid-soluble, GABA agonist. [15] The dosage is 1.5 mg/kg (usually 100 to 200 mg). It has quick onset of action, can cross the blood-brain barrier, wide tissue distribution, and can be hepatically cleared by the body quickly. [15] In the elderly, the rate of Propofol clearance is low.
The researchers also discovered that wristbands that cost more than $30 typically contained more fluorine than those priced under $15. The wristbands were also checked for 20 different types of ...