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On average, statins can lower LDL cholesterol by 1.8 mmol/L (70 mg/dL), which translates into an estimated 60% decrease in the number of cardiac events (heart attack, sudden cardiac death) and a 17% reduced risk of stroke after long-term treatment. [36] A greater benefit is observed with high-intensity statin therapy. [37]
Statins increase the risk of diabetes, [22] consistent with FDA's review, which reported a 27% increase in investigator-reported diabetes mellitus in rosuvastatin-treated people. [ 23 ] Drug interactions
[22] [23] Another consequence of taking statins is the risk of developing new-onset diabetes, which is more prominent in individuals with high TG levels and body mass index (BMI). [19] However, the risk is far outweighed by the benefits from statin therapy for the reduction in cardiovascular outcomes. [20]
As mentioned, Ozempic is approved by the FDA (U.S. Food and Drug Administration) as a diabetes drug to help those with type 2 diabetes manage their blood sugar levels. So, it is designed to be ...
The strongest risk factors are diabetes and smoking. Heart failure It’s referred to as chronic heart failure when it develops slowly over time or acute heart failure when it develops quickly.
Chen explained statins work by decreasing the amount of cholesterol made by the liver. “By doing that, it decreases your total circulating blood cholesterol levels,” he said. Statins do not ...
Statin-induced rhabdomyolysis is rare, occurring in less than 0.1% of people who take statins. [64] [65] [66] Statin induced rhabdomyolysis, as with other statin associated muscle symptoms, occurs most commonly in the first year of treatment but can occur at any time during treatment. [64]
A small increased risk of raised blood sugar levels and the development of type 2 diabetes have been reported with the use of statins. A 2010 published meta-analysis found for every 255 patients taking a statin for 4 years, one additional case of diabetes would occur whilst preventing 5.4 major coronary events. [27]