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However, randomized trials like the Beta-Carotene and Retinol Efficacy Trial (CARET) [22] and the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC Study) [23] revealed not only a lack of benefit but an increased risk of cancer, particularly lung cancer among smokers. These findings prompted a reevaluation of antioxidant ...
β-Carotene (beta-carotene) is an organic, strongly colored red-orange pigment abundant in fungi, [7] plants, and fruits. It is a member of the carotenes , which are terpenoids (isoprenoids), synthesized biochemically from eight isoprene units and thus having 40 carbons .
The study was done using supplements and researchers were aware of the epidemiological correlation between carotenoid-rich fruits and vegetables and lower lung cancer rates. The research concluded that no reduction in lung cancer was found in the participants using these supplements, and furthermore, these supplements may, in fact, have harmful ...
High doses of some antioxidants may have harmful long-term effects. The Beta-Carotene and Retinol Efficacy Trial (CARET) study of lung cancer patients found that smokers given supplements containing beta-carotene and vitamin A had increased rates of lung cancer. [140] Subsequent studies confirmed these adverse effects. [141]
Vitamin A is a fat-soluble vitamin that is an essential nutrient.The term "vitamin A" encompasses a group of chemically related organic compounds that includes retinol, retinyl esters, and several provitamin (precursor) carotenoids, most notably β-carotene (beta-carotene).
In addition to the main result, Ioannidis lists six corollaries for factors that can influence the reliability of published research. Research findings in a scientific field are less likely to be true, the smaller the studies conducted. the smaller the effect sizes. the greater the number and the lesser the selection of tested relationships.
Ching-Shih Chen (US), the former chair of cancer research at Ohio State University, was investigated by OSU and the federal Office of Research Integrity after being anonymously reported for falsifying data. The investigation found that Chen mishandled images and figures in published papers, "intentionally falsified data", and did not keep any ...
Small-cell lung carcinoma (SCLC) has long been divided into two clinicopathological stages, termed limited stage (LS) and extensive stage (ES). [8] The stage is generally determined by the presence or absence of metastases, whether or not the tumor appears limited to the thorax, and whether or not the entire tumor burden within the chest can feasibly be encompassed within a single radiotherapy ...