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A liquid biopsy, also known as fluid biopsy or fluid phase biopsy, is the sampling and analysis of non-solid biological tissue, primarily blood. [1] [2] Like traditional biopsy, this type of technique is mainly used as a diagnostic and monitoring tool for diseases such as cancer, with the added benefit of being largely non-invasive.
Cote co-edited two volumes in the "Current Cancer Research" book series: Circulating Tumor Cells: Advances in Basic Science and Clinical Applications with Ram Datar, and Advances in Liquid Biopsy Technologies with Evi Lianidou. About the first edition, academic Sudeep Gupta remarked, "This book is a contemporary and comprehensive collection of ...
Guardant Reveal, which runs on Guardant’s Smart Liquid Biopsy platform, is a blood test that uses epigenomic (methylation) analysis to detect circulating tumor DNA (ctDNA), a marker of minimal ...
Guardant Health said the test would be the "first and only comprehensive biopsy-free cancer test available". [7] In 2016, the company announced clinical trial results demonstrating the test "detected disease-associated genetic mutations that were also present in 94% to 100% of the solid tissues extracted from the study's subjects". [8]
The liquid biopsy is considered a minimally invasive procedure because, unlike other methods of tissue biopsy, such as the solid traditional tissue biopsy, it only necessitates a small amount of blood sample. Liquid biopsy testing has grown in acceptance in clinical settings due to its many advantages, which have assisted in the market's expansion.
ctDNA 'Liquid Biopsy' Could Revolutionize Cancer Care Nov 2014 Karachaliou N, Mayo-de-Las-Casas C, Molina-Vila MA, Rosell R (March 2015). "Real-time liquid biopsies become a reality in cancer treatment" .