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Mephedrone, also known as 4-methylmethcathinone, 4-MMC, and 4-methylephedrone, is a synthetic stimulant drug belonging to the amphetamine and cathinone classes. It is commonly referred to by slang names such as drone, [5] M-CAT, [6] white magic, [7] meow meow, and bubble. [8]
Effects of 4-CMC and mephedrone on inhibition of neurotransmitter uptake [3] Drug Uptake Inhibition at DAT. IC 50 (nM) Uptake Inhibition at NET. IC 50 (nM) Uptake Inhibition at SERT. IC 50 (nM) Mephedrone 769 ± 106 319 ± 40 600 ± 99 4-CMC 1014 ± 78 559 ± 57 542 ± 38
Methcathinone / ˌ m ɛ θ ˈ k æ θ ɪ ˌ n oʊ n / (α-methyl amino-propiophenone or ephedrone) (sometimes called "cat" or "jeff" or "catnip" or "M-Kat" or "kat" or "intash") is a monoamine alkaloid and psychoactive stimulant, a substituted cathinone.
3-Methylmethcathinone (3-MMC), also known as metaphedrone, [4] is a designer drug from the substituted cathinone family. 3-MMC is a monoamine transporter substrate (a substance acted upon by monoamine transporters) that potently releases and inhibits the reuptake of dopamine and norepinephrine, as well as displaying moderate serotonin releasing activity.
4-MC is a serotonin–norepinephrine–dopamine releasing agent (SNDRA) similarly to mephedrone. [ 5 ] [ 6 ] [ 7 ] It displays a 2.4-fold selectivity to promote monoamine release via DAT over SERT as opposed to 309-fold selectivity for cathinone . [ 6 ]
Its sale has been banned in Sweden since December 9, 2009. [3] It is a controlled substance in China since October 1, 2015. [21] Methedrone can be purchased legally in Europe (excluding Sweden) and in most states in the US on the Internet, but also it can also be found at head shops and other retailers. [22]
4-Methylethcathinone or 4-MEC is a chemical that bears a chemical resemblance to mephedrone. [3] Due to its similarity to mephedrone, it is thought to be a stimulant and entactogen drug of the phenethylamine, amphetamine, and cathinone chemical classes. [4]
In the UK, mephedrone, commonly known as MCAT, is the fourth most commonly used illicit drug among nightclub goers after cannabis, MDMA and cocaine. [7] Based on reports to the American Association of Poison Control Centers , use of bath salts in the US is thought to have increased significantly between 2010 and 2012. [ 7 ]