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RARs mediate transcription of different sets of genes controlling differentiation of a variety of cell types, thus the target genes regulated depend upon the target cells. [8] In some cells, one of the target genes is the gene for the retinoic acid receptor itself ( RAR-beta in mammals), which amplifies the response. [ 9 ]
RA also influences neural differentiation by regulating the expression of pro-neural induction factor Neurogenin 2 . RA affects cardiogenesis, as it plays a role specifically in the formation of the atrial chambers of the heart. RA also plays a role in the development of the pancreas, kidneys, lungs, and extremities. [10]
The retinoic acid receptor (RAR) is a type of nuclear receptor which can also act as a ligand-activated transcription factor [1] that is activated by both all-trans retinoic acid and 9-cis retinoic acid, retinoid active derivatives of Vitamin A. [2]
Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. [1] It typically results in warm, swollen, and painful joints. [1] Pain and stiffness often worsen following rest. [1] Most commonly, the wrist and hands are involved, with the same joints typically involved on both sides of the body. [1]
The RA development from demethylation of histones in the patient can lead to expression of high levels of IL-6 which causes destruction in the joints. [3] miRNAs also play an important part in rheumatoid arthritis development as well, particularly the upregulation of miRNA-146a and miRNA-150. Although more research is needed, lncRNAs have been ...
Rheumatoid arthritis (RA) is a disorder in which the body's own immune system starts to attack body tissues specifically the cartilage at the end of bones known as articular cartilage. [47] The attack is not only directed at the joint but to many other parts of the body.
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