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A beating heart awaiting transplant. American medical researcher Simon Flexner was one of the first people to mention the possibility of heart transplantation. In 1907, he wrote the paper "Tendencies in Pathology," in which he said that it would be possible one day by surgery to replace diseased human organs – including arteries, stomach, kidneys and heart.
If the organ donor is human, most countries require that the donor be legally dead for consideration of organ transplantation (e.g. cardiac death or brain death). For some organs, a living donor can be the source of the organ. For example, living donors can donate one kidney or part of their liver to a well-matched recipient. [2]
The operation typically lasts 8 to 12 hours. By comparison, a typical heart transplant operation lasts 6 to 8 hours. The recipient of a hand transplant needs to take immunosuppressive drugs, as the body's natural immune system will try to reject, or destroy, the hand. These drugs cause the recipient to have a weak immune system and react ...
This publication laid the groundwork for CIOMS' 1982, 1993, 2002, 2009, and 2016 versions of International Ethical Guidelines for Health-Related Research Involving Humans. [3] These guidelines have been praised for including diverse stakeholders from low- and middle-income countries, compared to the Declaration of Helsinki written by physicians ...
The individual criteria varies from one organ type to another. For example, with heart and lung transplantation, candidate recipients are given one of four status levels (1A - the highest level, 1B, 2, and 7). [18]
Similar to the concept of elective cardiopulmonary bypass, used in open heart surgery, oxygenation and perfusion can be maintained with an ECMO device in patients undergoing cardiovascular collapse. In the setting of cardiac arrest, ECPR involves percutaneous cannulation of a femoral vein and artery, followed by the activation of the device ...
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Organ transplantation is a medical procedure in which an organ is removed from one body and placed in the body of a recipient, to replace a damaged or missing organ. The donor and recipient may be at the same location, or organs may be transported from a donor site to another location.