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Neuronal fear pathways [ edit ] In fear conditioning, the main circuits that are involved are the sensory areas that process the conditioned and unconditioned stimuli, certain regions of the amygdala that undergo plasticity (or long-term potentiation) during learning, and the regions that bear an effect on the expression of specific conditioned ...
Pavlovian fear conditioning is a behavioral paradigm in which organisms learn to predict aversive events. [1] It is a form of learning in which an aversive stimulus (e.g. an electrical shock) is associated with a particular neutral context (e.g., a room) or neutral stimulus (e.g., a tone), resulting in the expression of fear responses to the originally neutral stimulus or context.
A heuristic model of the neural pathway of the Papez circuit shows the connections between its different parts. Based on Papez's experiment with aggression in rats and other studies, it was initially believed that the circuit was involved with emotion. The circuit connects the hypothalamus and the cortex and acts as the emotional system of the ...
Fear of the unknown or irrational fear is caused by negative thinking which arises from anxiety accompanied by a subjective sense of apprehension or dread. [23] Irrational fear shares a common neural pathway with other fears, a pathway that engages the nervous system to mobilize bodily resources in the face of danger or threat.
Fear memories, for example, are considered to be stored in the neuronal connections from the lateral nuclei to the central nucleus of the amygdalae and the bed nuclei of the stria terminalis (part of the extended amygdala). These connections are not the sole site of fear memories given that the nuclei of the amygdala receive and send ...
The mesolimbic pathway regulates incentive salience, motivation, reinforcement learning, and fear, among other cognitive processes. [14] [15] [16] The mesolimbic pathway is involved in motivational cognition. Depletion of dopamine in this pathway, or lesions at its site of origin, decrease the extent to which an animal is willing to go to ...
Joseph E. LeDoux (born December 7, 1949) is an American neuroscientist whose research is primarily focused on survival circuits, including their impacts on emotions such as fear and anxiety. [1]
The amygdala's role in learned fear includes interactions with other brain regions in the neural circuit of fear. While damage in the amygdala can inhibit its ability to recognize fearful stimuli, other areas such as the ventromedial prefrontal cortex and the basolateral nuclei of the amygdala can affect the region's ability to not only become ...