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“A brief return of symptoms may be part of the natural history of SARS-CoV-2 (the virus that causes COVID-19) infection in some persons, independent of treatment with Paxlovid and regardless of ...
Antiviral drugs are a class of antimicrobials, a larger group which also includes antibiotic (also termed antibacterial), antifungal and antiparasitic drugs, [3] or antiviral drugs based on monoclonal antibodies. [4] Most antivirals are considered relatively harmless to the host, and therefore can be used to treat infections.
Yet there is wide documentation of the low frequency of prescribing Paxlovid and other antivirals, and that can have significant consequences for higher-risk COVID-19 patients.
Aciclovir risks causing resistance to antiviral agents, and in 1% to 10% of cases can cause unpleasant side effects. [19] Aciclovir taken by mouth does not appear to decrease the risk of pain after shingles. [20] In those with herpes of the eye, aciclovir may be more effective and safer than idoxuridine. [21]
[28] [29] Ribavirin has also been used as a treatment for herpes simplex virus. One small study found that ribavirin treatment reduced the severity of herpes outbreaks and promoted recovery, as compared with placebo treatment. [30] Another study found that ribavirin potentiated the antiviral effect of acyclovir. [31]
Pritelivir (development codes AIC316 or BAY 57-1293) is a direct-acting antiviral drug in development for the treatment of herpes simplex virus infections (HSV). This is particularly important in immune compromised patients. It is currently in Phase III clinical development by the German biopharmaceutical company AiCuris Anti-infective Cures AG.
“Paxlovid will remain important for people at the highest risk of severe COVID-19, such as seniors and those with compromised immune systems,” a doctor told The Associated Press.
No participants had received a COVID‑19 vaccine or been previously infected with COVID‑19. [12] The main outcome measured in the trial was the proportion of people who were hospitalized due to COVID‑19 or died due to any cause during 28 days of follow-up. [12] EPIC-HR started in July 2021, and completed in December 2021. [51]